
Psychosomatics 47:385-391, September-October
doi: 10.1176/appi.psy.47.5.385
© 2006 Academy of Psychosomatic Medicine
Aripiprazole in the Treatment of Delirium
David A. Straker, D.O.,
Peter A. Shapiro, M.D., and
Philip R. Muskin, M.D.
Received May 12, 2005; revised September 5, 2005; accepted October 4, 2005. From the Dept. of ConsultationLiaison Psychiatry at New York Presbyterian Hospital, and the Columbia Univ. Medical Center. Address correspondence and reprint requests to Dr. David Straker, 850 Park Ave., Suite 1E, New York, NY 10021. e-mail: nyrpsychdoc{at}aol.com; das2115@columbia.edu
Antipsychotic drugs are the primary treatment for symptoms of delirium, but their side effects can be problematic. Treatment of delirium with aripiprazole has yet to be evaluated. The authors report on 14 patients with delirium treated with aripiprazole. Twelve patients had a 50% reduction in Delirium Rating Scale, Revised98 scores, and 13 showed improvement on Clinical Global Impression scale scores. There was a low rate of adverse side effects. Aripiprazole may be an appropriate first-line agent for the treatment of delirium because of its minimal effect on QTc interval, weight, lipids, and glucose levels. Controlled comparison studies should be performed to confirm this impression.
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G. L. Fricchione, S. H. Nejad, J. A. Esses, T. J. Cummings Jr., J. Querques, N. H. Cassem, and G. B. Murray
Postoperative Delirium
Am J Psychiatry,
July 1, 2008;
165(7):
803 - 812.
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