Psychosomatics 44:104-112, April 2003
© 2003 The Academy of Psychosomatic Medicine
A Prospective Study of Neuropsychiatric Symptoms Associated With Interferon- -2b and Ribavirin Therapy for Patients With Chronic Hepatitis C
Eric Dieperink, M.D.,
Samuel B. Ho, M.D.,
Paul Thuras, Ph.D., and
Mark L. Willenbring, M.D.
Received April 18, 2002; accepted Aug. 5, 2002. From the Veterans Affairs Medical Center, Minneapolis; and the Departments of Psychiatry and Medicine, University of Minnesota, Minneapolis. Address reprint requests to Dr. Willenbring, Department of Psychiatry (116A), VA Medical Center, One Veterans Dr., Minneapolis, MN 55417; Mark.Willenbring{at}med.va.gov (e-mail).
The purpose of this study was to systematically describe the neuropsychiatric side effects of treatment with interferon- -2b (INF-) and ribavirin in patients with chronic hepatitis C as well as to compare different instruments used to measure these side effects. Fifty-five patients with chronic hepatitis C were prospectively followed for 24 weeks and assessed with seven neuropsychiatric symptom measures and one quality of life scale. Of 42 patients treated with INF- and ribavirin, 11 (26%) were receiving psychiatric treatment at baseline. They scored higher on all rating scales at baseline and became more symptomatic during treatment. Of the 31 patients (74%) not in psychiatric care at baseline, 15 (48%) required treatment for neuropsychiatric symptoms, and seven (23%) met criteria for major depression during INF- therapy. The control group of 13 untreated subjects showed little change over the 24-week period. All symptom scales were highly intercorrelated, suggesting that use of one is sufficient for monitoring symptoms.
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